SCIENTIFIC EVIDENCE Anantra Rapid & Extended

The following section summarizes key properties of ANANTRA™’s ingredients as revealed by peer-reviewed scientific studies.

Eurycoma longifolia (Tongkat Ali)

Eurycoma longifolia (Tongkat Ali) is an endemic South East Asian plant with well-documented aphrodisiac, anti-diabetic & other properties in local traditional medicine (active substance: quassinoids).

  • A randomized clinical trial comparing intake of Tongat Ali extract vs. placebo with respect to the improvement of Quality of Life and Sexual Well-Being in Men (109 men) showed a 14% improvement in overall erectile function, as assayed by the International Index of Erectile Function (IIEF) questionnaire. In this study, Tongat Ali was safe and did not induce changes in standard biochemical markers (ALT/AST, urea, etc.) in patients1. Additional studies in patients of sub-fertile couples or patients suffering from hypogonadism showed improvement of semen parameters or other sexual funtions2-3.
  • Unlike some pharmaceutical ED inhibitors, Tongat Ali does not inhibit the main metabolic liver enzyme CYP3A4 or a variety of p450 metabolizing enzymes4; this is indicative of minimal potential to induce harmful drug interactions.
  • Additional clinical evidence in male (and female) seniors suggests Tongat Ali’s natural aphrodisiac properties may also be linked with enhanced ergogenesis (increased muscle strength, higher testosterone) in the absence of toxicity5.
  • Several positive animal studies are also supportive of a beneficial action of Tongkat Ali in libido enhancement and reproduction6-8.

Epimedium sagittatum (Horny Goat Weed)

Epimedium sagittatum (Horny Goat Weed) is plant with well documented aphrodisiac properties widely used in Chinese natural medicine (active substance: icariin).

  • Horny Goat Weed and Icariin have significant potencies against PDE5, the target of pharmacological ED inhibitors such as Viagra9.
  • Oral administration of lipid-based suspensions of Epimedium extracts improved erectile function of aged rats (e.g. increased number of ejaculations)10, while in-penis administration of Epimedium sagittatum elicited penile erection in rats11.
  • Epimedium was invoked as prior art (previous knowledge) by the US Patent Office against Pfizer; the Office listed Epimedium as the first documented example of treatment against erectile dysfunction, thus dismissing a relevant Viagra patent claim12.
  • Additional studies show that part of their aphrodisiac properties of Epimedium sagittatum active ingredients may be associated with reduction of mild stress or mood improvement13-14.

Panax Korean Ginseng

Panax Korean Ginseng is a plant shown to positively affect sexual parameters in human clinical trials (active substance: gingenosides).

  • A multicenter, placebo controlled, double blind clinical trial of Panax ginseng in 119 Korean men with erectile dysfunction showed a significant improvement in premature ejaculation diagnostic tool (PEDT) after 4 and 8 weeks of treatment versus placebo15. No discernible toxicity differences were noted between the two arms, suggesting that the product is safe15. Similar results were reported in multiple other trials16-18.
  • Panax ginseng administration for 4 weeks was shown to be safe, tolerable, and free of any untoward toxic effect in a randomized, placebo-controlled, clinical trial in healthy Korean volunteers19.

Tribulus terrestris

Tribulus terrestris is native in warm temperate and tropical regions. The plant has long been a constituent in tonics in Indian Ayurveda practice, while it is known as “bai ji li” in traditional Chinese medicine (active ingredients: saponins, flavonoids, glycosides).

  • A double-blind, controlled clinical study done in India in patients of 21-50 years old suggests a beneficial effect for the plant in oligospermia20; similar results have been obtained in animals21.
  • Tribulus terrestis supplementation improved Erectile Function, Sexual Quality of Life & Ejaculation Function in patients with mild-moderate erectile dysfunction in a prospective, randomized, placebo-controlled, single-blinded clinical study22.

Lepidium meyenii (Maca)

Lepidium meyenii (Maca) is a small plant native to the high Andes of Peru. The nutritional value of dried maca root is high, similar to cereal grains such as rice and wheat (active ingredients: proteins, carbohydrates, lipids, fiber & fatty acids).

  • Clinical trials performed in men have suggested that maca extracts can improve semen quality, and boost libido23.
  • Maca has a small, yet significant increase in the subjective perception of general and sexual well-being in adult patients with mild ED24.
  • A double-blind, randomized, parallel group dose-finding pilot study has shown that Maca root may alleviate selective-serotonin reuptake inhibitor (SSRI) induced sexual dysfunction25.

Other ANANTRA™ ingredients

L-arginine is an essential amino acid shown to be safe and effective as an oral, first-line treatment of erectile dysfunction in a controlled crossover study, whether alone26 or in combination with Vitamin B3 (niacin)27.

Vitamin B3 (niacin) alone can improve erectile function in patients suffering from moderate to severe ED and dyslipidemia28.

Magnesium & Manganese are trace metals with a purported role in spermatogenesis29-30.

Erectile dysfunction is associated with oxidative stress, suggesting that anti-oxidants may have a beneficiary effect, especially at the level of Nitric Oxide production, i.e.:

Green tea has known anti-oxidant properties and may improve erectile dysfunction in animals31.

Zinc, a metal generally considered as safe (FDA GRAS status), is a known anti-oxidant. Zinc contributes to fertility and reproduction, while it is essential for spermatogenesis32.

Selenium supplementation improves semen quality and has beneficial and protective effects on sperm motility33.

 

References

1 Evid Based Complement Alternat Med. 2012;2012:429268
2 Asian J Androl 12 (3):376-80. doi: 10.1038/aja.2010.7.
3 Andrologia 44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x.
4 J Nat Med. 2014 Apr;68(2):402-6.
5 Phytother Res. 2014 Apr;28(4):544-50
6 J Ethnopharmacol. 2013 Aug 26;149(1):201-7.
7 Reprod Domest Anim. 2011 Aug;46(4):573-8.
8 Andrologia. 2014 May;46(4)
9 J Nat Prod. 2008 Sep;71(9):1513-7.
10 J Ethnopharmacol. 2007 Dec 3;114(3):412-6.
11 Urology. 2006 Mar;67(3):631-5.
12 USPTO versus Pfizer patent claim
13 Pharmacol Biochem Behav. 2007 May;87(1):130-40
14 J Sex Med. 2010 Apr;7(4 Pt 1):1518-28
15 Int J Impot Res. 2013 Mar-Apr;25(2):45-50.
16 Asian J Androl 11 (3):356-61.
17 Korean J Androl. 2006 Aug;24(2):84-88.
18 Asian J Androl 9 (2):241-4.
19 J Altern Complement Med. 2012 Nov;18(11):1061-9
20 Ayu. 2012 Jul;33(3):356-64.
21 J Pharmacol Pharmacother. 2012 Jan;3(1):43-7.
22 Biomed Res Int. 2014;2014:121396
23 Evid Based Complement Alternat Med. 2012;2012:193496
24 Andrologia. 2009 Apr;41(2):95-9.
25 CNS Neurosci Ther. 2008 Fall;14(3):182-91
26 Urol Int. 1999;63(4):220-3.
27 Andrologia. 2012 May;44 Suppl 1:600-4.
28 J Sex Med. 2011 Oct;8(10):2883-93
29 Reprod Toxicol. 2001 Mar-Apr;15(2):131-6.
30 Reprod Toxicol. 2006 Nov;22(4):580-5.
31 Age (Dordr). 2008 Dec;30(4):217-28.
32 Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10859-64.
33 Int J Gen Med. 2011 Jan 23;4:99-104.